GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 628831
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISOCRRD:7341036480464CTDepigallocatechin gallate results in increased activity of NR1H4 protein

PMID:22178739
multiple interactionsISOCRRD:7341036480464CTD[epigallocatechin gallate co-treated with gallocatechol] results in increased activity of NR1H4 protein

epigallocatechin gallate inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]

epigallocatechin gallate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of NR1H4 mRNA]

epigallocatechin gallate inhibits the reaction [GW 4064 results in increased activity of NR1H4 protein]

epigallocatechin gallate inhibits the reaction [GW 4064 results in increased expression of NR1H4 mRNA]

PMID:22178739
multiple interactionsISOCRRD:7341046480464CTDNR1H4 protein affects the reaction [epigallocatechin gallate results in increased expression of FGF15 mRNA]

NR1H4 protein affects the reaction [epigallocatechin gallate results in increased expression of NR0B2 mRNA]

PMID:22178739
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.