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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730881
Species: Homo sapiens
CRRD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:107306480464CTDepigallocatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA], epigallocatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]

PMID:18656336
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.