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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733705
Species: Homo sapiens
CRRD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDepigallocatechin gallate results in decreased expression of CTNNB1 mRNA, epigallocatechin gallate results in decreased expression of CTNNB1 protein

PMID:16968065
decreases localizationEXP 6480464CTDepigallocatechin gallate results in decreased localization of CTNNB1 protein

PMID:16968065
decreases phosphorylationEXP 6480464CTDepigallocatechin gallate results in decreased phosphorylation of CTNNB1 protein

PMID:16968065
decreases expressionISORGD:15504666480464CTDepigallocatechin gallate results in decreased expression of CTNNB1 protein

PMID:12351151
multiple interactionsISORGD:15504666480464CTDepigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA], epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 protein]

PMID:27058323
multiple interactionsISORGD:704876480464CTDepigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of CTNNB1 protein]]

PMID:29999212
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.