Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733705
Species: Homo sapiens
CRRD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:48607
Term: lithium chloride
Definition: A metal chloride salt with a Li(+) counterion.
Chemical ID: MESH:D018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDLithium Chloride affects the localization of CTNNB1 protein, Lithium Chloride affects the localization of CTNNB1 protein modified form

PMID:22493441, PMID:24244343, PMID:24534281
decreases phosphorylationEXP 6480464CTDLithium Chloride results in decreased phosphorylation of CTNNB1 protein

PMID:16076840
increases expressionEXP 6480464CTDLithium Chloride results in increased expression of CTNNB1 mRNA, Lithium Chloride results in increased expression of CTNNB1 protein

PMID:16053526, PMID:16735606, PMID:20069066, PMID:28886972, PMID:28901456
multiple interactionsEXP 6480464CTD[Lithium Chloride co-treated with ESR1 protein] results in increased expression of CTNNB1 protein, [Lithium Chloride results in decreased activity of and results in increased phosphorylation of GSK3B protein] which results in increased expression of and results in increased phosphorylation of CTNNB1 protein, Arsenic Trioxide inhibits the reaction [Lithium Chloride results in increased expression of CTNNB1 protein], CTNNB1 protein affects the reaction [[Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 protein], CTNNB1 protein promotes the reaction [Lithium Chloride results in increased expression of POU5F1 mRNA], CTNNB1 protein promotes the reaction [Lithium Chloride results in increased expression of POU5F1 protein], Hexachlorophene inhibits the reaction [Lithium Chloride results in increased expression of CTNNB1 protein], Lithium Chloride inhibits the reaction [Aspirin results in increased phosphorylation of CTNNB1 protein], Lithium Chloride inhibits the reaction [hydroquinone results in decreased expression of CTNNB1 protein], Lithium Chloride inhibits the reaction [Indomethacin results in increased phosphorylation of CTNNB1 protein], Lithium Chloride inhibits the reaction [quinocetone results in decreased expression of CTNNB1 protein], Lithium Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CTNNB1 protein], Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein], Lithium Chloride promotes the reaction [CTNNB1 protein binds to FGF16 promoter], Lithium Chloride results in increased activity of [TCF4 protein co-treated with CTNNB1 protein], Lithium Chloride results in increased expression of and results in decreased phosphorylation of CTNNB1 protein, Lithium Chloride results in increased expression of and results in increased localization of CTNNB1 protein, Lithium Chloride results in increased expression of and results in increased phosphorylation of CTNNB1 protein, Lithium Chloride results in increased localization of and results in increased activity of CTNNB1 protein, MALAT1 protein affects the reaction [Lithium Chloride affects the localization of CTNNB1 protein], MALAT1 protein affects the reaction [Resveratrol inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]], N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein modified form], N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein], Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein], Resveratrol inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein], Resveratrol inhibits the reaction [Lithium Chloride results in increased activity of [TCF4 protein co-treated with CTNNB1 protein]], SFRP2 protein affects the reaction [Lithium Chloride results in increased expression of CTNNB1 mRNA], XAV939 inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]

PMID:12813129, PMID:16735606, PMID:19228266, PMID:19274078, PMID:19679347, PMID:20069066, PMID:20074550, PMID:20696143, PMID:22134133, PMID:22493441, PMID:22935447, PMID:23872260, PMID:24244343, PMID:24253043, PMID:24534281, PMID:26990689, PMID:28343033, PMID:28886972, PMID:28901456
increases activityISORGD:15504666480464CTDLithium Chloride results in increased activity of CTNNB1 protein

PMID:19582394, PMID:20118494
increases activityISORGD:704876480464CTDLithium Chloride results in increased activity of CTNNB1 protein

PMID:20694829
increases expressionISORGD:15504666480464CTDLithium Chloride results in increased expression of CTNNB1 mRNA, Lithium Chloride results in increased expression of CTNNB1 protein

PMID:22935447, PMID:27018151, PMID:27226553
increases expressionISORGD:704876480464CTDLithium Chloride results in increased expression of CTNNB1 mRNA

PMID:27045591
increases localizationISORGD:15504666480464CTDLithium Chloride results in increased localization of CTNNB1 protein

PMID:19442631
increases stabilityISORGD:15504666480464CTDLithium Chloride results in increased stability of CTNNB1 protein

PMID:23326414
multiple interactionsISORGD:15504666480464CTD[[Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased localization of CTNNB1 protein] which results in increased expression of GIP mRNA, [Lithium Chloride results in increased activity of CTNNB1 protein] which results in increased expression of GSTM3 mRNA, [Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased localization of CTNNB1 protein, Lithium Chloride inhibits the reaction [Paraquat results in decreased expression of CTNNB1 protein], Lithium Chloride inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CTNNB1 protein], Lithium Chloride promotes the reaction [[LEF1 protein co-treated with CTNNB1 protein] binds to GCG promoter], Lithium Chloride promotes the reaction [[LEF1 protein co-treated with CTNNB1 protein] binds to GIP promoter], Lithium Chloride promotes the reaction [CTNNB1 protein binds to GCG promoter], Lithium Chloride promotes the reaction [CTNNB1 protein binds to GIP promoter], Lithium Chloride results in increased expression of and affects the localization of CTNNB1 protein

PMID:15364539, PMID:19582394, PMID:20118494, PMID:27018151, PMID:30171970
multiple interactionsISORGD:704876480464CTD[[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein] which affects the expression of GJA1 protein, [Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein, CTNNB1 protein affects the reaction [Lithium Chloride results in increased expression of NR4A2 mRNA], Lithium Chloride inhibits the reaction [Doxorubicin results in decreased expression of CTNNB1 protein], Lithium Chloride inhibits the reaction [Heparin promotes the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]], Lithium Chloride inhibits the reaction [manganese chloride results in decreased expression of CTNNB1 protein], Lithium Chloride inhibits the reaction [Rotenone results in decreased expression of and results in decreased phosphorylation of CTNNB1 protein], Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein], Lithium Chloride promotes the reaction [CTNNB1 protein binds to NR4A2 promoter], Lithium Chloride promotes the reaction [CTNNB1 protein binds to NR4A2 protein]

PMID:18972237, PMID:23872260, PMID:24464479, PMID:27045591, PMID:30377735
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.