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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733705
Species: Homo sapiens
CRRD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:4887
Term: ethosuximide
Definition: A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Chemical ID: MESH:D005013
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDDKK1 protein inhibits the reaction [Ethosuximide results in decreased phosphorylation of CTNNB1 protein]

PMID:26420483
decreases phosphorylationISORGD:704876480464CTDEthosuximide results in decreased phosphorylation of CTNNB1 protein

PMID:26420483
increases expressionISORGD:704876480464CTDEthosuximide results in increased expression of CTNNB1 mRNA

PMID:26420483
multiple interactionsISORGD:704876480464CTDEthosuximide inhibits the reaction [APP protein modified form results in decreased expression of CTNNB1 mRNA]

PMID:26420483
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.