GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2687
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ghr
Name: growth hormone receptor
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of GHR mRNA

PMID:12075121
affects expressionISOCRRD:106446480464CTDEthinyl Estradiol affects the expression of GHR mRNA

PMID:17555576
multiple interactionsISOCRRD:106446480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GHR mRNA

PMID:17942748
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.