Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737411
Species: Homo sapiens
CRRD Object: Gene
Symbol: AQP8
Name: aquaporin 8
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7374126480464CTDEthinyl Estradiol affects the expression of AQP8 mRNA

PMID:17555576
decreases expressionISORGD:21466480464CTDEthinyl Estradiol results in decreased expression of AQP8 protein

PMID:17110522, PMID:18683753
increases expressionISORGD:21466480464CTDEthinyl Estradiol results in increased expression of AQP8 mRNA

PMID:15834898, PMID:16174780, PMID:17110522, PMID:17351261, PMID:18683753, PMID:24096037
increases expressionISORGD:7374126480464CTDEthinyl Estradiol results in increased expression of AQP8 mRNA

PMID:16174780, PMID:24096037
multiple interactionsISORGD:21466480464CTDleupeptin inhibits the reaction [Ethinyl Estradiol results in decreased expression of AQP8 protein]

PMID:17110522
multiple interactionsISORGD:7374126480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AQP8 mRNA

PMID:17942748
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.