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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:4948
Term: Evodiamine
Definition: A beta-carboline that has formula C19H17N3O.
Chemical ID: MESH:C049639
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases phosphorylationISORGD:105116480464CTDevodiamine results in increased phosphorylation of EGFR protein

PMID:19854188
multiple interactionsISORGD:105116480464CTDEGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein], EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein], EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PLCG1 protein], EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein], RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of EGFR protein]

PMID:19854188
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.