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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737414
Species: Mus musculus
CRRD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:49603
Term: lapatinib
Definition: A furan that has formula C29H26ClFN4O4S.
Chemical ID: MESH:C490728
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7374136480464CTD[lapatinib results in decreased susceptibility to lapatinib] which results in decreased expression of CDH1 protein, Niclosamide inhibits the reaction [[lapatinib results in decreased susceptibility to lapatinib] which results in decreased expression of CDH1 protein]

PMID:26643609
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.