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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69057
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:4998
Term: fenarimol
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fenarimol. A sterol demethylation inhibitor, it is used as a fungicide for the treatment of blackspot, mildew and rust in tomatoes, peppers and melons, but is not approved for use within the European Union.
Chemical ID: MESH:C033789
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISOCRRD:691056480464CTDfenarimol results in increased activity of NR1I2 protein

PMID:16565514
multiple interactionsISOCRRD:691056480464CTDfenarimol binds to and results in increased activity of NR1I2 protein

PMID:21115097
multiple interactionsISOCRRD:691066480464CTDfenarimol binds to and results in increased activity of NR1I2 protein

PMID:21115097
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.