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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDFenofibrate results in increased expression of NR0B2 mRNA

PMID:19593819
increases expressionISORGD:7328736480464CTDFenofibrate results in increased expression of NR0B2 mRNA, Fenofibrate results in increased expression of NR0B2 protein

PMID:19593819
increases expressionISORGD:7328746480464CTDFenofibrate results in increased expression of NR0B2 mRNA

PMID:19593819
multiple interactionsISORGD:7328736480464CTDDactinomycin inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA], dorsomorphin inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]], pyrazolanthrone inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA]

PMID:19593819
multiple interactionsISORGD:7328746480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of NR0B2 mRNA, NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]], NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of IL6 mRNA]], NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]], NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]], NR0B2 protein promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of CYP4A14 mRNA], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FAS mRNA]], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 mRNA]], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 mRNA]], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]]

PMID:19593819
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.