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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2466
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp2b1
Name: cytochrome P450, family 2, subfamily b, polypeptide 1
Acc ID: CHEBI:5063
Term: fipronil
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fipronil.
Chemical ID: MESH:C082360
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDfipronil results in increased expression of CYP2B1 mRNA

PMID:23962444
increases expressionISORGD:15583116480464CTDfipronil results in increased expression of CYP2B10 mRNA

PMID:23962444
multiple interactionsISORGD:15583116480464CTDNR1I3 gene mutant form inhibits the reaction [fipronil results in increased expression of CYP2B10 mRNA]

PMID:23962444
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.