GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 727915
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp27a1
Name: cytochrome P450, family 27, subfamily a, polypeptide 1
Acc ID: CHEBI:50686
Term: atorvastatin calcium
Definition: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
Chemical ID: MESH:D000069059
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:13466136480464CTDAtorvastatin results in decreased expression of CYP27A1 mRNA

Atorvastatin results in decreased expression of CYP27A1 protein

PMID:16386711
increases expressionISOCRRD:15504756480464CTDAtorvastatin results in increased expression of CYP27A1 mRNA

PMID:25278499
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.