GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620707
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tff1
Name: trefoil factor 1
Acc ID: CHEBI:51348
Term: tetraphene
Definition: An angular ortho-fused polycyclic arene consisting of four fused benzene rings.
Chemical ID: MESH:C030935
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:13446716480464CTDbenz(a)anthracene results in increased expression of TFF1 mRNA

benz(a)anthracene results in increased expression of TFF1 protein

PMID:22643241
increases expressionISOCRRD:7320176480464CTDbenz(a)anthracene results in increased expression of TFF1 mRNA

PMID:26377693
multiple interactionsISOCRRD:13446716480464CTD2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]

2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 protein]]

[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]

bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]

bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 protein]]

fulvestrant inhibits the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]

fulvestrant inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]

Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]

Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]

Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 protein]

PMID:22643241
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.