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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 68332
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pde1c
Name: phosphodiesterase 1C
Acc ID: CHEBI:5163
Term: fosinopril
Definition: A phosphinate ester-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. It is used for the treatment of hypertension and heart failure. A pro-drug, it is hydrolysed in vivo to the corresponding phosphininc acid, fosinoprilat, which is the active metabolite.
Chemical ID: MESH:D017328
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDFosinopril affects the expression of PDE1C mRNA, Fosinopril affects the expression of PDE1C protein

PMID:18209565
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.