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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:51913
Term: Goe 6976
Definition: An indolocarbazole that has formula C24H18N4O.
Chemical ID: MESH:C081021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDGo 6976 inhibits the reaction [irinotecan metabolite results in increased phosphorylation of EGFR protein], Go 6976 inhibits the reaction [irinotecan results in increased phosphorylation of EGFR protein]

PMID:15723263
multiple interactionsISORGD:25436480464CTDGo 6976 inhibits the reaction [EGF protein binds to and results in increased localization of EGFR protein]

PMID:11134345
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.