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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1563633
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Edem1
Name: ER degradation enhancing alpha-mannosidase like protein 1
Acc ID: CHEBI:52172
Term: nilotinib
Definition: A carboxamide that has formula C28H22F3N7O.
Chemical ID: MESH:C498826
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13497596480464CTD4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of EDEM1 mRNA

PMID:23883479
multiple interactionsISORGD:13497596480464CTDarsenic trioxide promotes the reaction [4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of EDEM1 mRNA]

PMID:23883479
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.