GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621543
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Chek2
Name: checkpoint kinase 2
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases phosphorylationISOCRRD:7328616480464CTDwortmannin results in decreased phosphorylation of CHEK2 protein

PMID:22119920
multiple interactionsISOCRRD:7328616480464CTDwortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of CHEK2 protein]

wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK2 protein]

PMID:19111594, PMID:22119920
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.