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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621612
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nts
Name: neurotensin
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13190926480464CTDwortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein], wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein], wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein], wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:15177934
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.