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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Adam10
Name: ADAM metallopeptidase domain 10
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:7358476480464CTDBortezomib results in decreased expression of ADAM10 mRNA

PMID:20977926
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