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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2443
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cth
Name: cystathionine gamma-lyase
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7320846480464CTD[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of CTH mRNA

PMID:25522274
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.