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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 62051
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pla2g5
Name: phospholipase A2, group V
Acc ID: CHEBI:53490
Term: N-formyl-L-methionyl-L-leucyl-L-phenylalanine
Definition: A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.
Chemical ID: MESH:D009240
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:7353286480464CTDN-Formylmethionine Leucyl-Phenylalanine results in increased activity of PLA2G5 protein

PMID:11741884
increases secretionISORGD:7353286480464CTDN-Formylmethionine Leucyl-Phenylalanine results in increased secretion of PLA2G5 protein

PMID:11741884
multiple interactionsISORGD:7353286480464CTDPLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Arachidonic Acid], PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]

PMID:9495842
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.