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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620029
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Acc ID: CHEBI:5613
Term: haloperidol
Definition: A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.
Chemical ID: MESH:D006220
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDHaloperidol results in decreased expression of NR4A1 mRNA

PMID:11564422
increases expressionEXP 6480464CTDHaloperidol results in increased expression of NR4A1 mRNA

PMID:10987852, PMID:19695244
multiple interactionsEXP 6480464CTD8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of NR4A1 mRNA]

PMID:19695244
affects response to substanceISORGD:7327526480464CTDNR4A1 affects the susceptibility to Haloperidol

PMID:14603264
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.