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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621612
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nts
Name: neurotensin
Acc ID: CHEBI:5613
Term: haloperidol
Definition: A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.
Chemical ID: MESH:D006220
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDHaloperidol results in increased expression of NTS mRNA, Haloperidol results in increased expression of NTS protein

PMID:10199625, PMID:11602683, PMID:12887421
multiple interactionsEXP 6480464CTD8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA], Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]

PMID:10199625
increases expressionISORGD:13190936480464CTDHaloperidol results in increased expression of NTS mRNA

PMID:11120399, PMID:14603264, PMID:14698760
multiple interactionsISORGD:13190936480464CTDSLC6A3 protein promotes the reaction [Haloperidol results in increased expression of NTS mRNA]

PMID:14698760
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.