Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 14180349
Species: Sus scrofa
CRRD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: CHEBI:5855
Term: ibuprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Chemical ID: MESH:D007052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3decreases expressionEXP 6480464CTDIbuprofen results in decreased expression of NOS3 mRNA

PMID:10525081, PMID:10644584
NOS3multiple interactionsEXP 6480464CTD11-deoxy-16-phenoxy-17, 18, 19, 20-tetranorprostaglandin E1 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA], 11-deoxyprostaglandin E1 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA], 16, 16-Dimethylprostaglandin E2 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA], sulprostone inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]

PMID:10525081
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.