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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2078
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ak4
Name: adenylate kinase 4
Acc ID: CHEBI:5864
Term: ifosfamide
Definition: The simplest member of the class of ifosfamides that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by 2-chloroethyl groups on both the nitrogen atoms respectively. It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer.
Chemical ID: MESH:D007069
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:16065916480464CTDIfosfamide results in increased expression of AK4 mRNA

PMID:25596134
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.