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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620872
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: F2rl3
Name: F2R like thrombin or trypsin receptor 3
Acc ID: CHEBI:59173
Term: bivalirudin
Definition: A synthetic peptide of 20 amino acids, comprising D-Phe, Pro, Arg, Pro, Gly, Gly, Gly, Gly, Asn, Gly, Asp, Phe, Glu, Glu, Ile, Pro, Glu, Glu, Tyr, and Leu in sequence. A congener of hirudin (a naturally occurring drug found in the saliva of the medicinal leech), it a specific and reversible inhibitor of thrombin, and is used as an anticoagulant.
Chemical ID: MESH:C074619
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:13513656480464CTDbivalirudin results in decreased activity of F2RL3 protein

PMID:19124943
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.