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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1315197
Species: Homo sapiens
CRRD Object: Gene
Symbol: DHCR24
Name: 24-dehydrocholesterol reductase
Acc ID: CHEBI:59224
Term: cetrorelix
Definition: A synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-tyrosyl, N(5)-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.
Chemical ID: MESH:C062876
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DHCR24 mRNA, [cetrorelix co-treated with testosterone enanthate] results in decreased expression of DHCR24 mRNA

PMID:18160741
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.