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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2059
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:59877
Term: enalaprilat dihydrate
Definition: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.
Chemical ID: MESH:D015773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDEnalaprilat affects the expression of ADRB1 protein

PMID:9260993
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.