GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69057
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:6067
Term: isotretinoin
Definition: A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases.
Chemical ID: MESH:D015474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISOCRRD:691056480464CTDIsotretinoin results in increased activity of NR1I2 protein

PMID:25455453
multiple interactionsISOCRRD:691056480464CTD[Isotretinoin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

Isotretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]

PMID:16632523, PMID:25455453
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.