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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730858
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL2
Name: interleukin 2
Acc ID: CHEBI:61057
Term: tacrolimus hydrate
Definition: A hydrate that is the monohydrate form of tacrolimus.
Chemical ID: MESH:D016559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTacrolimus results in decreased expression of IL2 protein

PMID:11407316
multiple interactionsEXP 6480464CTD[Tacrolimus co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA, Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL2 protein], Tacrolimus inhibits the reaction [CD2 protein results in increased expression of IL2 protein], Tacrolimus inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of IL2 protein], Tacrolimus inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA], Tacrolimus inhibits the reaction [Zinc Sulfate inhibits the reaction [Mitogens results in increased expression of IL2 mRNA]]

PMID:1371491, PMID:16055081, PMID:1705513, PMID:24603311, PMID:29594315
decreases expressionISORGD:6200476480464CTDTacrolimus results in decreased expression of IL2 mRNA

PMID:12126653
decreases expressionISORGD:7333156480464CTDTacrolimus results in decreased expression of IL2 mRNA, Tacrolimus results in decreased expression of IL2 protein

PMID:1701765, PMID:8986461
multiple interactionsISORGD:7333156480464CTDTacrolimus affects the reaction [[9, 10-Dimethyl-1, 2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL2 protein], Tacrolimus inhibits the reaction [Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]]

PMID:1614535, PMID:25770929
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.