Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:61399
Term: canertinib
Definition: A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a propenamido group at the 6-position, and a 3-morpholinopropoxy group at the 7-position.
Chemical ID: MESH:C420268
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDCanertinib results in decreased activity of EGFR protein, Canertinib results in decreased activity of EGFR protein mutant form

decreases phosphorylationEXP 6480464CTDCanertinib results in decreased phosphorylation of EGFR protein

multiple interactionsEXP 6480464CTDCanertinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

multiple interactionsISORGD:105116480464CTDCanertinib inhibits the reaction [Acetaminophen affects the localization of EGFR protein], Canertinib inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of EGFR protein]

Go Back to source page   Continue to Ontology report


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.