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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:61399
Term: canertinib
Definition: A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a propenamido group at the 6-position, and a 3-morpholinopropoxy group at the 7-position.
Chemical ID: MESH:C420268
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDCanertinib results in decreased activity of EGFR protein, Canertinib results in decreased activity of EGFR protein mutant form

PMID:21322567
decreases phosphorylationEXP 6480464CTDCanertinib results in decreased phosphorylation of EGFR protein

PMID:15956251
multiple interactionsEXP 6480464CTDCanertinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

PMID:18927496
multiple interactionsISORGD:105116480464CTDCanertinib inhibits the reaction [Acetaminophen affects the localization of EGFR protein], Canertinib inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of EGFR protein]

PMID:28123000
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.