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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1321715
Species: Mus musculus
CRRD Object: Gene
Symbol: Flt3
Name: FMS-like tyrosine kinase 3
Acc ID: CHEBI:63452
Term: midostaurin
Definition: An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.
Chemical ID: MESH:C059539
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:13217146480464CTDmidostaurin results in decreased activity of FLT3 protein

PMID:21980431
decreases response to substanceISORGD:13217146480464CTDFLT3 protein results in decreased susceptibility to midostaurin

PMID:21980431
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.