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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:63577
Term: lamivudine
Definition: A monothioacetal that consists of cytosine having a (2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl moiety attached at position 1. An inhibitor of HIV-1 reverse transcriptase, it is used as an antiviral in the treatment of AIDS and hepatitis B.
Chemical ID: MESH:D019259
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:621786480464CTD[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA, [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA, [Zidovudine co-treated with Lamivudine] results in increased expression of TIMP2 mRNA

PMID:16931933
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.