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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3074
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Me1
Name: malic enzyme 1
Acc ID: CHEBI:63581
Term: stavudine
Definition: A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase
Chemical ID: MESH:D018119
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:108906480464CTDStavudine results in increased expression of ME1 mRNA

PMID:11741158
multiple interactionsISORGD:108906480464CTD[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA, [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of ME1 mRNA, [Stavudine co-treated with Lamivudine] results in increased expression of ME1 mRNA

PMID:11741158
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.