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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621295
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mvk
Name: mevalonate kinase
Acc ID: CHEBI:63630
Term: tolcapone
Definition: Benzophenone substituted on one of the phenyl rings at C-3 and C-4 by hydroxy groups and at C-5 by a nitro group, and on the other phenyl ring by a methyl group at C-4. It is an inhibitor of catechol O-methyltransferase.
Chemical ID: MESH:C066340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDtolcapone results in increased expression of MVK mRNA

PMID:24136188
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