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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69274
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Casp2
Name: caspase 2
Acc ID: CHEBI:63632
Term: topotecan
Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Chemical ID: MESH:D019772
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[oxaliplatin co-treated with Topotecan] results in decreased expression of CASP2 mRNA

PMID:25729387
increases cleavageISORGD:16048506480464CTDTopotecan results in increased cleavage of CASP2 protein

PMID:19812371
increases cleavageISORGD:7314606480464CTDTopotecan results in increased cleavage of CASP2 protein

PMID:19812371
multiple interactionsISORGD:16048506480464CTDbenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Topotecan results in increased cleavage of CASP2 protein], pifithrin promotes the reaction [Topotecan results in increased cleavage of CASP2 protein], TP53 inhibits the reaction [Topotecan results in increased cleavage of CASP2 protein]

PMID:19812371
multiple interactionsISORGD:7314606480464CTDAPAF1 promotes the reaction [Topotecan results in increased cleavage of CASP2 protein], benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Topotecan results in increased cleavage of CASP2 protein], TRP53 inhibits the reaction [Topotecan results in increased cleavage of CASP2 protein]

PMID:19812371
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.