GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1306661
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Chuk
Name: component of inhibitor of nuclear factor kappa B kinase complex
Acc ID: CHEBI:63892
Term: zerumbone
Definition: A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.
Chemical ID: MESH:C403304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:13154016480464CTDzerumbone inhibits the reaction [CHUK protein results in increased activity of [NFKB1 protein binds to RELA protein]]

zerumbone inhibits the reaction [TNF protein results in increased activity of CHUK protein]

PMID:16007145
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.