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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3910
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tshb
Name: thyroid stimulating hormone subunit beta
Acc ID: CHEBI:63933
Term: Aroclor 1254
Definition: A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).
Chemical ID: MESH:D020111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDChlorodiphenyl (54% Chlorine) results in decreased expression of TSHB protein

PMID:16298753
increases expressionEXP 6480464CTDChlorodiphenyl (54% Chlorine) results in increased expression of TSHB protein

PMID:20655938
multiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of TSHB protein], Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of TSHB protein]

PMID:16298753
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.