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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620018
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gzmb
Name: granzyme B
Acc ID: CHEBI:63954
Term: ionomycin
Definition: A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at position 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes.
Chemical ID: MESH:D015759
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7330226480464CTD2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GZMB protein], [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GZMB protein

PMID:30171972
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.