Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737062
Species: Homo sapiens
CRRD Object: Gene
Symbol: PRKCA
Name: protein kinase C alpha
Acc ID: CHEBI:64017
Term: (5Z,8Z,11Z,13E)-15-HETE
Definition: A HETE that is (5Z,8Z,11Z,13E)-15-hydroxyicosa-5,8,11,13-tetraenoic acid bearing a hydroxy substituent at position 15.
Chemical ID: MESH:C025984
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTD15-hydroxy-5, 8, 11, 13-eicosatetraenoic acid affects the localization of PRKCA protein

PMID:15613483
multiple interactionsEXP 6480464CTD15-hydroxy-5, 8, 11, 13-eicosatetraenoic acid promotes the reaction [EGF protein affects the localization of PRKCA protein], 15-hydroxy-5, 8, 11, 13-eicosatetraenoic acid promotes the reaction [HGF protein affects the localization of PRKCA protein]

PMID:15613483
increases activityISORGD:7370636480464CTD15-hydroxy-5, 8, 11, 13-eicosatetraenoic acid results in increased activity of PRKCA protein

PMID:15451026
multiple interactionsISORGD:7370636480464CTDcalphostin C inhibits the reaction [15-hydroxy-5, 8, 11, 13-eicosatetraenoic acid results in increased activity of PRKCA protein]

PMID:15451026
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.