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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2414
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cryab
Name: crystallin, alpha B
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7375186480464CTDtert-Butylhydroperoxide results in decreased expression of CRYAB mRNA

PMID:15336504
increases expressionISORGD:7375186480464CTDtert-Butylhydroperoxide results in increased expression of CRYAB mRNA

PMID:20847119
multiple interactionsISORGD:7375186480464CTD[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CRYAB mRNA, [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CRYAB mRNA, [troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CRYAB mRNA, pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CRYAB mRNA], troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CRYAB mRNA]

PMID:20847119
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.