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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDtert-Butylhydroperoxide results in increased expression of APAF1 protein

PMID:15877105
multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein]

PMID:15877105
increases expressionISORGD:7332936480464CTDtert-Butylhydroperoxide results in increased expression of APAF1 protein

PMID:17419000
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.