GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 67383
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Prkcd
Name: protein kinase C, delta
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceEXP 6480464CTDPRKCD mRNA affects the susceptibility to 1-Methyl-4-phenylpyridinium

PMID:15033169
increases cleavageEXP 6480464CTD1-Methyl-4-phenylpyridinium results in increased cleavage of PRKCD protein

PMID:15033169
multiple interactionsEXP 6480464CTDbenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of PRKCD protein]

benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of PRKCD protein]

PMID:15033169
decreases expressionISOCRRD:690266480464CTD1-Methyl-4-phenylpyridinium results in decreased expression of PRKCD mRNA

PMID:25234470
increases expressionISOCRRD:690266480464CTD1-Methyl-4-phenylpyridinium results in increased expression of PRKCD mRNA

PMID:24810058
increases expressionISOCRRD:690276480464CTD1-Methyl-4-phenylpyridinium results in increased expression of PRKCD mRNA

PMID:22776087
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.