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CRRD ID: 1321715
Species: Mus musculus
CRRD Object: Gene
Symbol: Flt3
Name: FMS-like tyrosine kinase 3
Acc ID: CHEBI:64153
Term: tanespimycin
Definition: A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects.
Chemical ID: MESH:C112765
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13217146480464CTDtanespimycin results in decreased expression of FLT3 protein

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.