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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:64227
Term: ciglitazone
Definition: An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
Chemical ID: MESH:C039671
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDciglitazone results in decreased expression of EGFR protein

PMID:21080969
multiple interactionsEXP 6480464CTDciglitazone inhibits the reaction [CREBBP protein binds to EGFR promoter], ciglitazone inhibits the reaction [NCOA1 protein binds to EGFR promoter], CREBBP protein inhibits the reaction [ciglitazone results in decreased expression of EGFR protein], NCOA1 protein inhibits the reaction [ciglitazone results in decreased expression of EGFR protein]

PMID:21080969
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.