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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:64310
Term: crizotinib
Definition: A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
Chemical ID: MESH:C551994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceEXP 6480464CTDEGFR protein mutant form results in decreased susceptibility to crizotinib, EGFR protein results in decreased susceptibility to crizotinib

PMID:21791641, PMID:22235099
multiple interactionsEXP 6480464CTD[EGFR protein results in increased phosphorylation of EGFR protein] which results in decreased susceptibility to crizotinib, EGFR protein promotes the reaction [EGF protein results in decreased susceptibility to crizotinib], EGFR protein promotes the reaction [HBEGF protein results in decreased susceptibility to crizotinib], EGFR protein promotes the reaction [TGFA protein results in decreased susceptibility to crizotinib]

PMID:22277784, PMID:22553343
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.