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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1310844
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Dusp10
Name: dual specificity phosphatase 10
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13219796480464CTDandrographolide results in increased expression of DUSP10 mRNA, andrographolide results in increased expression of DUSP10 protein

PMID:29165873
multiple interactionsISORGD:13219796480464CTD1H-(1, 2, 4)oxadiazolo(4, 3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA], 1H-(1, 2, 4)oxadiazolo(4, 3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 protein], DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]], DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]], HMOX1 protein promotes the reaction [andrographolide results in increased expression of DUSP10 protein], zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA], zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 protein]

PMID:29165873
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.