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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1312683
Species: Homo sapiens
CRRD Object: Gene
Symbol: EZH2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDandrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein], IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]]

PMID:31128153
multiple interactionsISORGD:13126846480464CTDandrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]

PMID:31128153
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.