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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621628
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Slc22a12
Name: solute carrier family 22 member 12
Acc ID: CHEBI:6541
Term: losartan
Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Chemical ID: MESH:D019808
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:13235436480464CTDSLC22A12 protein affects the susceptibility to Losartan

PMID:18670416
decreases activityISORGD:13235436480464CTDLosartan results in decreased activity of SLC22A12 protein

PMID:20486468
decreases expressionISORGD:13235436480464CTDLosartan results in decreased expression of SLC22A12 mRNA

PMID:20486468
multiple interactionsISORGD:13235436480464CTD[Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid

PMID:18670416
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.